KMID : 1024520200290080837
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Journal of the Environmental Sciences 2020 Volume.29 No. 8 p.837 ~ p.846
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Effect of Momordica charantia on Glucagon Secretion in High-fat diet(HFD)/Streptozotocin(STZ)-induced Diabetic Rat
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Kim Seong-Eun
Kim Sang-Back Kim Seul-Ki Kim Hyun-Kyu Park Byoung-Jun Lee Hak-Sung
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Abstract
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In present study, we investigated the antidiabetic effect of Momordica charantia(as well known ¡°bitter melon¡±). This study was conducted to determine antidiabetic mechanism of Bitter Melon Extract (BME). We measured blood glucose, insulin, glucagon level in a Sprague-Dawley rat model of high-fat diet/streptozotocin(HFD/STZ)-induced diabetes. Five experimental groups were used: normal, HFD/STZ, BME 62.5 mg/kg HFD/STZ, BME 125 mg/kg HFD/STZ and BME 250 mg/kg HFD/STZ. BME was orally administered to the rats every other day for 9 weeks. Results showed that fasting blood glucose levels were significantly lower in the BME 125 mg/kg(150.17 ¡¾ 20.22 mg/dL) and 250 mg/kg(124.17 ¡¾ 22.17 mg/dL) groups than in the vehicle group(188.83 ¡¾ 26.63 mg/dL)(p<0.05). In addition, glucagon levels were lower in the three BME treatment groups than in the vehicle group(p<0.05). Oral glucose tolerance tests revealed that the BME 250 mg/kg group had significantly(p<0.05) reduced 120-minute blood glucose levels and areas under the curve. Our results suggest that BME induces antidiabetic effects via the reduction of glucagon and blood glucose levels.
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KEYWORD
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Momordica charantia, Diabetes, Blood sugar, Glucagon, Health supplement
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